In conclusion, we demonstrated that a total of 10 irradiations with low-intensity laser therapy significantly lowers the incidence of local recurrence of herpes simplex infection. Since this athermic phototherapeutic modality represents a safe, noninvasive treatment, it might be considered as an alternative to established therapeutic regimens in this indication.
OPEN FILE810 nm diode laser irradiation and ICG causes the greatest reduction in number of HSV1 compared to all the other groups.
OPEN FILEThe main advantages of the laser treatment appear to be the absence of side effects and drug interactions, which are especially helpful for older and immunocompromised patients.
OPEN FILETreatment with diode laser reduced the length of recovery time and pain severity faster than treatment with acyclovir cream.
OPEN FILELLLTof herpes simples virus 1 (HSV-1) appears to be an effective treatment modality without any observed side effects.
OPEN FILEOur results lead us to hypothesize that LD-irradiation acts in the final stage of HSV-1 replication by limiting viral spread from cell to cell and that laser therapy acts also on the host immune response unblocking the suppression of proinflammatory mediators induced by accumulation of progeny virus in infected epithelial cells.
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